Reply--Lanthanum hepatotoxicity-debate

Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats.

BACKGROUND Lanthanum (La) carbonate is an effective phosphate-binder, used to reverse hyperphosphataemia due to chronic kidney disease. Some recent studies in rodents have cast safety uncertainties. The aims of this study were to examine the effects of La on parathyroid hormone (PTH) gene expression and hepatic toxicity. METHODS Uraemia was induced in rats by a 0.3% adenine-containing diet fo...

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The best approach to reintroducing tuberculosis treatment after hepatotoxicity is still open to debate.

Potential conflicts of interest.D.R.K. has served as a consultant for and has received speaker’s fees and research support from Boehringer-Ingelheim, Bristol-Myers Squibb, and GlaxoSmithKline. R.M.G. has received research grants (awarded to Cornell University) from Merck and has served as an ad hoc consultant to BoehringerIngelheim, Bristol-Myers Squibb, Gilead, GlaxoSmithKline, and Merck. All ...

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Lanthanum carbonate